New G-quadruplex DNA structures
نویسندگان
چکیده
منابع مشابه
FANCJ promotes DNA synthesis through G-quadruplex structures
Our genome contains many G-rich sequences, which have the propensity to fold into stable secondary DNA structures called G4 or G-quadruplex structures. These structures have been implicated in cellular processes such as gene regulation and telomere maintenance. However, G4 sequences are prone to mutations particularly upon replication stress or in the absence of specific helicases. To investiga...
متن کاملG-quadruplex unfolding in higher-order DNA structures.
G-quadruplex unfolding within a sequence of two quadruplex units was characterized by gel electrophoresis, calorimetry and spectroscopy. The obtained results suggest that the kinetics and thermodynamics of the individual quadruplex unfolding are affected by its interaction with other DNA secondary structural elements.
متن کاملQuantitative visualization of DNA G-quadruplex structures in human cells.
Four-stranded G-quadruplex nucleic acid structures are of great interest as their high thermodynamic stability under near-physiological conditions suggests that they could form in cells. Here we report the generation and application of an engineered, structure-specific antibody employed to quantitatively visualize DNA G-quadruplex structures in human cells. We show explicitly that G-quadruplex ...
متن کاملFANCJ promotes replication of G-quadruplex DNA structures
Thank you again for submitting your manuscript EMBOJ-2014-88663, "FANCJ promotes replication of G-quadruplex DNA structures." We have now received all the reports from three experts, which I am enclosing copied below. As you will see, the reviewers express some interest in the basic finding of your study, yet they also raise a number of substantive concerns, and issues with the potential to con...
متن کاملAnthracene-terpyridine metal complexes as new G-quadruplex DNA binders.
The formation of quadruple-stranded DNA induced by planar metal complexes has particular interest in the development of novel anticancer drugs. This is especially relevant for the inhibition of telomerase, which plays an essential role in cancer cell immortalization and is overexpressed in ca. 85-90% of cancer cells. Moreover, G-quadruplexes also exist in other locations in the human genome, na...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2015
ISSN: 2053-2733
DOI: 10.1107/s2053273315096242